Rand0m1y's Signal-to-Noise Ratio: 2019

As an addendum to my previous post, Immortality for All, I feel I should update reader(s) on the situation.

Restoration to youth, approximately matching the same age as the bone marrow donating clone, has now be achieved.

Please bear with me, there have been a few updates to the initial draft of this blog entry. "Jim, I'm a Software Developer not a Doctor!", alas there's no scope for iterative development in the preparation of ground breaking medical procedures obtained thru the funny papers! There is some vague peer review process in place, hence the many updates.

The procedure is new, I don't have the exact details. The method has evolved from the knowledge of Hematologists and Obstetricians. I'm sure the usual life extension clinics will be offering this treatment in the coming months. Many of the first trials have been carried out in France and Canada, by what seems to be 25% elderly people and the remainder as a rejuvenation treatment for beauty. If the sentence or elements of "Over 50% bone marrow transplant using G-CSF and Pleraxifor", is something your clinic is aware of, perhaps you can judge their response and determine how to proceed or find one that knows the procedure.

In recent years new blood stem cell, bone marrow, mobilization drugs have become available and trusted [1], the limits for donation thoroughly researched. The process of bone marrow transplantation I believe has been developed as a palliative care treatment for post chemotherapy patients, immediately restoring missing blood stem cells.

Without chemotherapy; that is any cell destructive processes, and with the help of these drugs it is now possible to transplant 20 to 30ml/kg of the donor body mass, typically 1500ml-2500ml or more for an adult male, I believe a donation of 85% has been achieved.

What seems to be critical here, is that the patient receives over 50% in donated bone marrow, since the majority stem cells will eventually prevail. I would assume that the more over 50% you receive, the quicker you achieve the age of the clone in health and aspect.

For example, a patient weighing 80kg after removing 75% of their bone marrow, would require from a donor weighing 60kg more than 33.3% of the donor's bone marrow. I'm not sure how much more, I would assume at least 10% to be safe. The less bone marrow you have, the more time will be required to reach the age of the clone. As much bone marrow as possible should be removed from the recipient patient, as the transplanted bone marrow will multiply by cell subdivision to fill the missing volume.

I would like to say with some certainty how much time is required to match the age of the clone, although I believe this is in the order of months rather than years. I believe stem cell replication rate reduces with age, tho so far have only been able to determine that stem cells skew with age, that is favor the male or female chromosome instead of the 50/50 we probably need.

The bone marrow mobilization drugs G-CSF used in combination with Plerixafor are used over a period of 8 days to remove the patients bone marrow, with the donor undergoing a similar process 4 days later, concurrently transplanting bone marrow to the patient during the additional 4 days. I'm told the first day yields about 50% of the removable bone marrow, with 25% on subsequent days, however I'm not sure how accurate this data is. There are a few temporary side effects from the drugs, you might want to check online or consult the doctor for details. Apheresis is relatively pain free, where aspiration for bone marrow harvesting may require a longer period in hospital if a general anesthetic is used.

For reassurance: sickle-cell anemia was cured in a teenager. From just a few edited cells using CRISPR, the patients entire bone marrow was replaced; from a few stem cells to approximately 0.5bn, 1.5kg or 99.5% of the patients, without any side effects so far. This successful treatment gave scientists the confidence to proceed in attempting to replace all bone marrow in elderly patients.

All being well this method should make the patient approximately the same age as the clone within a period of months, perhaps a year or two for completion [2]. Eukaryotic life is a fountain, or perhaps a volcano of cells that almost entirely and continuously replaces the organism within a few days to a couple of years.


Cell renewal rates in different tissues of the human body. Values are rounded to one significant digit. (Courtesy of book.bionumbers.org)

How will you look afterwards? I am told, very much like the clone, with the stipulation that the patient looks the same age as the clone to a stranger. I think the nose is slightly larger, as this cartilaginous bone continues to grow throughout life. The body is a bit larger generally, though this could be attributed to the slow replacement process of the skeleton which takes 7-10 years to complete. Age, wisdom and confidence make us appear a little bit older of course.

How long will you live? I anticipate forever, with all your old fallen arches and whatever other mileage you've accumulated. I am told the best way to avoid such mileage is to carry out this process more frequently; stronger bones and the skin's elasticity are preserved. Of course this requires more clones. Perhaps a means of cultivating bone marrow outside of the body could be developed, editing telomere length using CRISPR. At present this process is hindered by the fact that bone marrow lives for a limited duration ex vitro.

I must apologize, much of the procedure here is conjecture. Though I am going to try this myself, please do consult a good hematologist and obstetrician or a good clinic. The good news however is that none of this is carcinogenic: no radiation or chemotherapy drugs that destroy cells in any way.

These front pages from May 2017 onward hint at an unfolding revelation, secret science murmurings from the biological research community. Note that concurrent with the 50ml experiment, other experiments were replacing far greater quantities in excess of 50% of the patients bone marrow.

Einstein contemplating his reflection which seems to be getting younger. Whilst not immediately relevant, the cover of May 2017's National Geographic hints at the murmurings occurring in the biological research community.

May 5th 2017